Timothy J Mitchison Selected Research

Antimitotic Agents

6/2015	In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.
10/2013	Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay.
2/2012	Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
7/2011	Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.
7/2011	Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.
11/2008	Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.

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Timothy J Mitchison Research Topics

Disease

29	Neoplasms (Cancer) 11/2021 - 06/2005
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 03/2004
3	Breast Neoplasms (Breast Cancer) 12/2018 - 11/2008
2	Bites and Stings (Sting) 12/2014 - 07/2013
2	Blister (Bulla) 03/2008 - 11/2006
1	Virus Diseases (Viral Diseases) 04/2022
1	Infections 04/2022
1	Body Weight (Weight, Body) 01/2019
1	Tauopathies 01/2019
1	Cachexia 01/2019
1	Hyperplasia 01/2019
1	Brain Neoplasms (Brain Tumor) 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 01/2018
1	Gout 01/2016
1	Familial Mediterranean Fever (Periodic Disease) 01/2016
1	Pericarditis 01/2016
1	Leukemia 01/2016
1	Fibrosarcoma 06/2015
1	Inflammation (Inflammations) 04/2015
1	Carcinogenesis 05/2014
1	Necrosis 01/2012
1	Wounds and Injuries (Trauma) 06/2009
1	Rheumatoid Arthritis 04/2006
1	Chromosomal Instability (Chromosome Stability) 06/2005
1	Confusion (Bewilderment) 10/2004
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 03/2004

Drug/Important Bio-Agent (IBA)

12	Pharmaceutical PreparationsIBA 01/2021 - 11/2008
8	Proteins (Proteins, Gene)FDA Link 04/2022 - 03/2004
6	Antimitotic AgentsIBA 06/2015 - 11/2008
5	Phosphotransferases (Kinase)IBA 01/2020 - 05/2014
4	Paclitaxel (Taxol)FDA LinkGeneric 11/2018 - 07/2011
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2015
3	Taxoids (Taxanes)IBA 11/2018 - 01/2016
2	Interferon Type IIBA 04/2022 - 01/2021
2	Vinca AlkaloidsIBA 01/2017 - 01/2016
2	vadimezanIBA 07/2013 - 01/2012
2	FlavonoidsIBA 07/2013 - 01/2012
2	KinesinsIBA 02/2006 - 10/2004
1	Viral ProteinsIBA 04/2022
1	ChromatinIBA 11/2021
1	Granzymes (Granzyme)IBA 01/2021
1	Nucleic AcidsIBA 01/2021
1	CollagenIBA 01/2020
1	TubulinIBA 01/2020
1	tau Proteins (tau Protein)IBA 01/2019
1	matrigelIBA 01/2019
1	XenobioticsIBA 01/2019
1	Vinblastine (Vinblastine Sulfate)FDA Link 01/2018
1	Polo-like KinasesIBA 01/2017
1	Colchicine FDA LinkGeneric 01/2016
1	eIF-4BIBA 01/2016
1	Protein Kinases (Protein Kinase)IBA 01/2016
1	Poly Adenosine Diphosphate RiboseIBA 04/2015
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 04/2015
1	ProteomeIBA 01/2015
1	SerpinsIBA 12/2014
1	Vaccine AdjuvantsIBA 12/2014
1	DNA (Deoxyribonucleic Acid)IBA 12/2014
1	Cytotoxins (Cytolysins)IBA 11/2014
1	taxaneIBA 11/2014
1	eribulin FDA Link 11/2014
1	Phenobarbital (Luminal)FDA Link 05/2014
1	Estrogens (Estrogen)FDA Link 05/2014
1	Progesterone Receptors (Progesterone Receptor)IBA 05/2014
1	CytokinesIBA 07/2013
1	bis(3',5')-cyclic diguanylic acidIBA 07/2013
1	InterferonsIBA 07/2013
1	LigandsIBA 07/2013
1	Pathogen-Associated Molecular Pattern MoleculesIBA 07/2013
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 07/2013
1	fosbretabulin (combretastatin A4)IBA 01/2012
1	navitoclaxIBA 07/2011
1	Small Interfering RNA (siRNA)IBA 10/2009
1	Dual OxidasesIBA 06/2009
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 06/2009
1	Biological ProductsIBA 06/2009
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2009
1	LipidsIBA 03/2008
1	Myosin Type IIIBA 03/2008
1	GoldIBA 04/2006
1	monastrolIBA 02/2006
1	cincreasinIBA 06/2005

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 01/2017 - 06/2005
3	Therapeutics 01/2018 - 02/2006
1	Immunotherapy 01/2021